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Research & Publications

22+Peer-Reviewed Publications

7New England Journal Papers

42+Clinical Trials Conducted

20+As Principal Investigator

—— Peer-Reviewed Publications

Published Where Medicine Listens

Dr. Jain’s research appears in the most cited medical journals on earth — the publications that define global cardiac practice.

NEJM

7 Papers

The New England Journal of Medicine — the world’s most influential medical journal. CORONARY, STICH, CANTOS, TIPS and transfusion landmark trials.

JAMA

Kidney Function After CABG

Journal of the American Medical Association — randomized clinical trial on off-pump vs on-pump bypass, 2014.

Circulation

Mitral Repair & Survival

The American Heart Association’s flagship journal — ischemic heart failure surgery outcomes from the STICH trial.

JACC

2 Papers

Journal of the American College of Cardiology — Yoga-based cardiac rehabilitation and the TRIA polymer mitral valve.

—— Selected Works

Landmark Publications

  1. Coronary Artery Bypass Surgery in Patients with Left Ventricular DysfunctionThe New England Journal of Medicine · 2011 · CORONARY Investigators.
  2. Myocardial Viability and Survival in Ischemic Left Ventricular DysfunctionThe New England Journal of Medicine · 2011 · STICH Trial.
  3. Off-Pump or On-Pump Coronary-Artery Bypass Grafting at 30 DaysThe New England Journal of Medicine · 2012 · CORONARY Investigators.
  4. Influence of Mitral Regurgitation Repair on Survival in the Surgical Treatment for Ischemic Heart Failure TrialCirculation (American Heart Association) · 2012.
  5. Effects of Off-Pump and On-Pump Coronary-Artery Bypass Grafting at 1 YearThe New England Journal of Medicine · 2013 · CORONARY Investigators.
  6. Kidney Function After Off-Pump or On-Pump Coronary Artery Bypass Graft Surgery — A Randomized Clinical TrialJAMA · 2014.
  7. Anti-Inflammatory Therapy with Canakinumab for Atherosclerotic DiseaseThe New England Journal of Medicine · 2017 · CANTOS Trial.
  8. Efficacy and Safety of Sacubitril/Valsartan in Chronic Heart Failure — PARADIGM-HF India Sub-StudyIndian Heart Journal (Elsevier) · 2020 · First author: Anil Ranjeetmal Jain.
  9. One-Year Results from a Multi-Center Trial of a Polymer Surgical Mitral ValveJournal of the American College of Cardiology · TRIA™ LifePolymer valve.
  10. Three-Year Outcomes of Surgical Valve Replacement with Dafodil™ Pericardial BioprosthesisFrontiers in Cardiovascular Medicine · 2024 · Dafodil™-1 Trial.

And where it all began — as early as 2006, Dr. Jain was publishing first-author papers on Surgical Ventricular Restoration and cardiac volume reduction in the Indian Journal of Thoracic & Cardiovascular Surgery, years before the world’s landmark trials validated the field he had already pioneered.

—— Heart Care Research LLP

The Trial Portfolio

Phase I – IV

24 Drug Trials

From PARADIGM-HF and FOURIER to CANTOS and PROMINENT — the therapies now standard in global heart failure and lipid care were tested here.

First-in-Human

8 Device Trials

Principal Investigator in the first-in-human Dafodil™ valve study, the Foldax TRIA™ aortic and mitral polymer valve investigations, and more.

Global Registries

10 Observational Studies

STICH, CORONARY, RBC, TRICS III, Yoga-CaRe, LAAOS III — the landmark registries that shaped modern surgical practice.

—— Recruiting Today

Active Research, Right Now

Research at EPIC never pauses. These trials are actively enrolling under Dr. Jain’s leadership today.

Active · PI

Dafodil™-1 Valve Trial

First-in-human study of the Dafodil pericardial bioprosthesis for aortic and mitral valve replacement.

Active · PI

Lipoprotein(a) Lowering — TQJ230

Phase III multicenter trial assessing Lp(a) reduction on major cardiovascular events.

Active · PI

VICTORION Program — Inclisiran

VICTORION-1 & 2 PREVENT — next-generation siRNA cholesterol therapy for high-risk patients.

Active · PI

HERMES — Ziltivekimab

Phase III trial in heart failure with systemic inflammation — the next frontier of anti-inflammatory cardiology.

Active · PI

TIN816 — Kidney Protection

Phase II study protecting patients from acute kidney injury following cardiac surgery.

Active

IIRIS & TRIO-2 Registries

National registries tracking aortic bioprosthesis and TricValve transcatheter outcomes across India.

—— On the Global Stage

Conferences & Faculty Roles

  1. Guest Speaker — 13th Annual London Core Review Cardiothoracic Surgery Course, 2024Presented his experience with the Dafodil™ bioprosthesis and surgical techniques for SVR & IMR repair — London, UK.
  2. Speaker — TCT Conference 2024, HyderabadThe TRIA Mitral Valve with LifePolymer: Redefining the Future of Heart Valve Treatment.
  3. Host — Transcatheter Aortic Valve Implantation Workshop 2024With IACTS, at EPIC Hospital, Ahmedabad.
  4. Organizing Committee — 66th Annual IACTS Conference 2020, AhmedabadPresented four papers including IMR Repair/Replace decision-making and the PRESERVE-Mitral Registry interim results.
  5. Speaker — 5th Annual Conference, Heart Failure Association of India, 2019Presented: MR — Repair or Replace? The Leela Ambience, Gurugram.
  6. Director, Organizing Committee — Joint International Conference 2005800+ delegates with 50+ international faculty — in association with AAPI & AACIO.
  7. Organizer & Director — 1st National Heart Valve Repair & Heart Failure Surgery WorkshopWith Dr. Jeffery Tyner, Dr. Aiden Raney & Dr. Pravin Shah.
  8. Director — 3-C Con Series 2006, 2007 & 2008Novelties & Advances in Cardiovascular Medicine — organized by The Heart Care Clinic, Ahmedabad.

Care informed by the world's best evidence

When you consult Dr. Jain, you consult the research itself — published in NEJM, JAMA, Circulation and JACC.

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